Endocrinology News

NHS in England to offer artificial pancreas to help manage type 1 diabetes

Successful trial of groundbreaking device, now approved by Nice, uses algorithm to determine amount of insulin needed More than 100,000 people with type 1 diabetes in England are to be offered an artificial pancreas, which experts believe could become the “holy grail” for managing the disease. The groundbreaking device uses an algorithm

Empagliflozin, irrespective of blood pressure, improves outcomes in heart failure with preserved ejection fraction: the EMPEROR Preserved trial

Ref: Michael Böhm, European Heart Journal (2022) 00, 1–12, https://doi.org/10.1093/eurheartj/ehac693 Empagliflozin reduced cardiovascular death and heart failure hospitalization in patients with preserved ejection fraction. Hypertension is the most common comorbidity and etiological trigger of heart failure with preserved ejection fraction (HFpEF) as pressure overload produces left ventricular hypertrophy, diastolic dysfunction,

Lean Diabetes: A Unique form of Diabetes

Ref: Diabetes Care 2022;45:1428–1437 | https://doi.org/10.2337/dc21-1957 Introduction The incidence of unique form of diabetes among individuals with low body mass index (BMI; <19 kg/m2) has been long recognized. Formally classified as “malnutrition-related diabetes mellitus” (MRDM) by the World Health Organization (WHO), this form of diabetes has a high prevalence in

Girls with type 1 diabetes may have worse cardiometabolic metrics than boys

Adapted from Endocrine Today By Erin T. Welsh, MA, Sept 23, 2022 Source: de Vries SAG, et al. Abstract #469. Presented at: European Association for the Study of Diabetes Annual Meeting; Sept. 19-23, 2022; Stockholm (hybrid meeting). Researchers observed sex disparities among children with type 1 diabetes, according to a presenter

Impact of Empagliflozin on Markers of Liver Steatosis and Fibrosis, and their Association with Cardiorenal Outcomes

Ref: Diabetes  Obes Metab.2022;24:1061–1071, DOI: 10.1111/dom.14670 Introduction Patients with type-2 diabetes mellitus (T2DM) are predisposed towards developing non-alcoholic fatty liver disease (NAFLD). Nearly 20% patients with NAFLD also have hepatic fibrosis, which is a strong predictor of NAFLD-mortality. Recent studies have demonstrated the beneficial impact of empagliflozin treatment on hepatic

Association of depression and parasympathetic activation with glycaemic control in type 2 diabetes mellitus (T2DM)

Ref: Kun-DerLin etal., Association of depression and parasympathetic activation with glycaemic control in type 2 diabetes mellitus, Journal of Diabetes and Its Complications (JDC), Available online 12 July 2022, 108264, https://doi.org/10.1016/j.jdiacomp.2022.108264 Abstract Aim Patients with type 2 diabetes mellitus exhibited autonomic nervous system (ANS) dysfunction and comorbidities with depressive or anxiety

Rapid Progression of CKD in T2DM

Ref: Csaba P. Kovesdy,  Chronic kidney disease progression among patients with type 2 diabetes identified in US administrative claims: a population cohort study, Clinical Kidney Journal, 2021, vol. 14, no. 6, 1657–1664,  doi: 10.1093/ckj/sfaa200 Introduction Chronic kidney disease (CKD) is one of the most common complications of type 2 diabetes

Effectiveness, safety, and tolerability of vildagliptin or vildagliptin/metformin combination in patients with type 2 diabetes uncontrolled on insulin (The OMEGA study)

Ref: Ibrahim El Ebrashy, Effectiveness, safety, and tolerability of vildagliptin or vildagliptin/metformin combination in patients with type 2 diabetes uncontrolled on insulin therapy in a real-world setting in Egypt: The OMEGA study, Diabetes Res Clin Pract.2020 Apr; 162:108042.  doi: 10.1016/j.diabres.2020.108042. Objective: To evaluate the effectiveness and safety of vildagliptin or